Reduced arginine availability results
in reduced NO synthesis. Arginine availability for
NO synthesis is regulated by de novo arginine
synthesis, arginase activity, and cellular arginine
transport. Arginase is generated by excessive NO levels,
and is to be avoided under any circumstance in an
L-Arginine or NO formula.
Excess (excessive) NO creates
a toxic environment in the human body, and low levels
of NO (reduced endogenous NO) are ineffective,
so NO highs and lows are to be avoided. In terms of
fertility in males, NO reduces or inhibits sperm motility,
while NOS inhibitors, which inhibit the formation
of NO, prevent the reduction of sperm motility, indicating
a role for the L-arginine-NO pathway in the modulation
of sperm motility and motility survival.
Sperm motility is negatively affective
by both reduced and excessive endogenous Nitric Oxide
(NO). The mechanism of reduced fertility in
males, related to NO, is a function of the effect
of reactive oxygen species (ROS) on sperm membranes,
which depresses sperm function. Stress also exacerbates
reduced motility of sperm. Excessive NO levels in
seminal plasma are associated with poor sperm
quality.
Excessive generation of NO can be
toxic and reduce sperm motility. Further, excessive
NO contributes to the formation of a highly toxic
anion of peroxidation, called peroxynitrite. The unpaired
electrons of NO and O2 define peroxynitrite as a 1-or-2-electron
oxidant and nitrating agent, and not a typical free
radical.
Numerous clinical studies have demonstrated
that peroxidation decreases sperm count and motility,
and loss of the capacity of the spermatozoon to undergo
the acrosome reaction and fertilization.
Therefore, NO formulas and products
must be produced under strict GMP manufacturing guidelines
utilizing long-term proven methodologies
in L-arginine biochemistry.
The manufacture of NO formulas and products should
not be attempted by persons unfamiliar with L-Arginine
NO toxic byproducts and the Blind Amino Acid
personality of amino acids, such as Arginine. Click
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